Cell mediated immune responses against human prion protein
نویسندگان
چکیده
منابع مشابه
Prion protein protects human neurons against Bax-mediated apoptosis.
The function of the cellular prion protein (PrP) is still poorly understood. We present here an unprecedented role for PrP against Bax-mediated neuronal apoptosis and show that PrP potently inhibits Bax-induced cell death in human primary neurons. Deletion of four octapeptide repeats of PrP (PrPDeltaOR) and familial D178N and T183A PrP mutations completely or partially eliminate the neuroprotec...
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In prion diseases, such as variant Creutzfeldt-Jakob disease normal cellular prion protein (PrPC), a largely alpha-helical structure is converted to an abnormal conformational isoform (PrPSc) that shows an increase in beta-sheet content. Similarly, the recombinant form of PrPC (ralpha-PrP) can be converted to a conformation dominated by beta-sheet (rbeta-PrP) by reduction and mild acidification...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2003
ISSN: 0009-9104
DOI: 10.1046/j.1365-2249.2003.02242.x